Our Pipeline.
The start in our effort to change the way we treat cancer.
OxyLo’s ProCaps Platform
Many solid tumors become inoperable because of their depth, location, or the risks of surgery. In these settings—including liver, pancreatic, and rectal cancers—systemic therapies are often limited by toxicity, and local treatments may not deliver sufficient drug exposure throughout the tumor.
ProCaps® addresses this delivery bottleneck. OxyLo’s enzyme-loaded biodegradable microcapsules are designed for local tumor delivery, where they convert systemically administered inactive prodrugs into active chemotherapy directly at the disease site. The underlying enzyme–prodrug biology has been clinically validated in humans; OxyLo’s innovation is enabling localized, controllable delivery for solid tumors.
By generating drug within the tumor microenvironment, ProCaps is designed to increase local therapeutic activity while limiting systemic exposure, with the potential for bystander killing beyond the immediate microcapsule location.
Learn more about our technology here: https://www.pnas.org/doi/abs/10.1073/pnas.2217557120
Our pipeline
Building on the vascular blockade from embolizing with our beads, our lead assets incorporate enzymes that rapidly convert FDA approved prodrugs into more potent forms directly at the tumor site, converting passive embolization into a powerful dual-action therapy.
Method of treatment
Liver tumors draw most of their nutrition from an unusually dense arterial network, making them prime targets for embolization therapy. By delivering ProCaps® directly into these vessels, we first block the blood supply, depriving the cancer of incoming fuel. Each micro-capsule then goes further: packed with enzymes, it rapidly converts FDA approved prodrugs into more potent chemotherapies, compounding starvation and amplifying tumor death. The result is a double hit of mechanical embolization plus metabolic shutdown, designed to collapse even the most vascular tumors with a single, minimally-invasive injection.
Learn more about how our science works here.